Immune checkpoint blockade (ICB) is efficacious in many diverse cancer types, but not all patients respond. It is important to understand the mechanisms driving resistance to these treatments and to identify predictive biomarkers of response to provi
Publications by authors named "Debattama R Sen" 10 Publications A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade.
The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. Our work lies at the interface of human immunology, systems biology, and functional epigenomics – merging clinical observations with mechanistic mouse studies to develop novel therapeutic strategies. Debattama Sen @DebattamaSen Feb 26 Incredibly cool story (and platform) studying the development of exhausted T cells from @ZeyuCHEN19 @EJohnWherry @junwei_s . Debattama R. Sen. Principal Investigator, Massachusetts General Hospital. Verified email at mgh.harvard.edu - Homepage. t cell exhaustion epigenetics … Debattama Saha Biography Wikipedia. Debattama Saha was born on 21 March in Silchar, Assam.
She is interested in immunology and computational biology, and is looking to combine the two interests through interdisciplinary research. She first worked at the lab in summer of 2011 through the Harvard Immunology Summer Research program, and… Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proc Natl Acad Sci U S A. 2020 09 … Debattama (Deb) Sen, PhD is a Principal Investigator in the Massachusetts General Hospital Center for Cancer Research and a faculty member at Harvard Medical School. She received her B.S. from Columbia University in Biomedical Engineering & Computer Science before training with Nick Haining at the Dana-Farber Cancer Institute. Debattama (Deb) Sen Principal Investigator at Harvard Medical School and Massachusetts General Hospital Greater Boston 480 connections Debattama R. Sen's 17 research works with 1,391 citations and 5,588 reads, including: A bilateral tumor model identifies transcriptional programs associated with patient response to immune Debattama Sen. Co-Author.
Debattama R. Sen1,2,*, James Kaminski3,*, R. Anthony Barnitz1, Makoto Kurachi4,5, Ulrike Sen et al. Page 3 Science. Author manuscript; available in PMC 2017 December 02. ipt. finding in single-cell clones and found that the expression of PD-1 in clones with a biallelic
With chronically infected mice as their model, the researchers used a new technology called ATAC-seq to map the regulatory regions of the genome – … Debattama R. Sen1,2,*, James Kaminski3,*, R. Anthony Barnitz1, Makoto Kurachi4,5, Ulrike Sen et al. Page 3 Science.
2016-11-04 · Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasikanth Manne, Jernej Godec, Omar Khan, Adam M. Drake, Zeyu Chen, Debattama Sen, Makoto Kurachi, R
Page 3 Science. Author manuscript; available in PMC 2017 December 02. ipt.
Debattama R. Sen's 17 research works with 1,391 citations and 5,588 reads, including: A bilateral tumor model identifies transcriptional programs associated with patient response to immune
SEN-DISSERTATION-2019.pdf (33.38Mb) Author. Sen, Debattama R. Metadata Show full item record. Citation Sen, Debattama R. 2019. Epigenetic Determinants of CD8+ T Cell
Debattama R Sen 1 2 , James Kaminski 3 , R Anthony Barnitz 1 , Makoto Kurachi 4 5 , Ulrike Gerdemann 1 , Kathleen B Yates 1 , Hsiao-Wei Tsao 1 , Jernej Godec 1 2 , Martin W LaFleur 1 2 , Flavian D Brown 1 2 , Pierre Tonnerre 6 , Raymond T Chung 6 , Damien C Tully 7 , Todd M Allen 7 , Nicole Frahm 8 , Georg M Lauer 6 , E John Wherry 4 5 , Nir
Immune checkpoint blockade (ICB) is efficacious in many diverse cancer types, but not all patients respond.
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12 Division of Pediatric Hematology and Oncology, Children's Hospital, Boston, 2011 Ruth and William Silen, M.D. Honorable Mention Recipients: Debattama Sen and Komal Kothari. Debattama Sen – College Student Columbia University. Komal Kothari – College Student Columbia University. Ignacio Salas – College Student University of California Berkeley.
With chronically infected mice as their model, the researchers used a new technology called ATAC-seq to map the regulatory regions of the genome – …
Debattama R. Sen1,2,*, James Kaminski3,*, R. Anthony Barnitz1, Makoto Kurachi4,5, Ulrike Sen et al. Page 3 Science. Author manuscript; available in PMC 2017 December 02.
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The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. Our work lies at the interface of human immunology, systems biology, and functional epigenomics – merging clinical observations with mechanistic mouse studies to develop novel therapeutic strategies.
1 . PTPN2 regulates the generation of exhausted CD8 + T cell subpopulations and restrains tumor immunity .
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Debattama R Sen. This person is not on ResearchGate, or hasn't claimed this research yet. James Kaminski. James Kaminski. This person is not on ResearchGate, or hasn't claimed this research yet.
Disrupting enhancers Debattama Sen Benjamin Shih David Wasser Due: May 26, 2006 Block A . 2 THE PROBLEM Introduction Deicers are an important part of life in places experiencing cold Debattama Saha. 2,315 likes · 97 talking about this.
Debattama Sen retweeted. Letters of Note @LettersOfNote. Jan 20. On this day in letters. 25. 327. 867. Debattama Sen retweeted. Steve Stewart-Williams @SteveStuWill
Epigenetic Determinants of CD8+ T Cell Exhaustion.
His elder daughter Debattama is currently a Principal Investigator at Massachusetts General Hospital and Faculty Member at Harvard Medical School after completing her PhD in Immunology at Harvard. 10 Department of Electrical Engineering and Computer Science, University of California, Berkeley, Berkeley, CA 94720, USA. 11 Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. niryosef@berkeley.edu nicholas_haining@dfci.harvard.edu. 12 Division of Pediatric Hematology and Oncology, Children's Hospital, Boston, 2011 Ruth and William Silen, M.D. Honorable Mention Recipients: Debattama Sen and Komal Kothari. Debattama Sen – College Student Columbia University. Komal Kothari – College Student Columbia University. Ignacio Salas – College Student University of California Berkeley.